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Biology

ORNL Team Enlists World’s Fastest Supercomputer to Combat the Coronavirus
3 months ago

ORNL Team Enlists World’s Fastest Supercomputer to Combat the Coronavirus

By  •  3 months ago  •  Featured, Science

Researchers at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL) have used the world’s most powerful and smartest supercomputer, the IBM AC922 Summit, to identify 77 small-molecule drug …
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Chromosome Connectors Take Center Stage for ORNL Scientists Studying Poplar
8 months ago

Chromosome Connectors Take Center Stage for ORNL Scientists Studying Poplar

By  •  8 months ago  •  Featured, Science

The black cottonwood tree, or Populus trichocarpa (poplar), serves as a model organism for scientists studying the structure, growth, development, and genetics of plants. Poplar was the first tree genome scientists …
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Summit Charts a Course to Uncover the Origins of Genetic Diseases
1 year ago

Summit Charts a Course to Uncover the Origins of Genetic Diseases

By  •  1 year ago  •  Featured, Science

A visualization of a new structure of the human PIC. The spheres correspond to the positions of patient-derived mutations color-coded by disease phenotype. Video credit: Ivaylo Ivanov, …
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Genomics Code Exceeds Exaops on Summit Supercomputer
2 years ago

Genomics Code Exceeds Exaops on Summit Supercomputer

By  •  2 years ago  •  Featured, Technology

Researchers at the US Department of Energy’s Oak Ridge National Laboratory broke the exascale barrier, achieving a peak throughput of 1.88 exaops—faster than any previously reported science application—while analyzing genomic …
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A Novel Method for Comparing Plant Genes
2 years ago

A Novel Method for Comparing Plant Genes

By  •  2 years ago  •  Science

During normal photosynthesis, plants capture sunlight and carry out respiration during the day, taking in carbon dioxide that will be used to form carbohydrates. But a small percentage of plant …
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Sodium Shakedown in Dopamine Research
3 years ago

Sodium Shakedown in Dopamine Research

By  •  3 years ago  •  Science

The chemical neurotransmitter dopamine is critical to sending and receiving signals in the nervous system linked to motor movements, learning, and habit formation, which is why many therapies for drug …
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A Real CAM-Do Attitude
3 years ago

A Real CAM-Do Attitude

By  •  3 years ago  •  Science

Photosynthesis, the method plants use to convert energy from the sun into food, is a ubiquitous process many people learn about in elementary school. Almost all plants use photosynthesis to …
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One Billion Processor Hours Awarded to 22 Projects through ALCC
4 years ago

One Billion Processor Hours Awarded to 22 Projects through ALCC

By  •  4 years ago  •  Science

The US Department of Energy (DOE) Office of Science has awarded nearly 1 billion processor hours to 22 projects at the Oak Ridge Leadership Computing Facility (OLCF)— a DOE Office …
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Broadening the Bilayer
4 years ago

Broadening the Bilayer

By  •  4 years ago  •  Science

To better understand the biological processes that govern lipid raft formation—processes with broad implications for research ranging from how cells regulate proteins to how viruses invade healthy human cells—ORNL researchers are using two world-class research facilities to study the presence and formation of these nanoscale lipid patches.
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Researchers recruit Titan to study key molecular switch that controls cell behavior

By  •  6 years ago  •  Science

Using computational molecular dynamics simulations, researchers at ORNL and the University of Tennessee–ORNL Joint Institute for Computational Sciences have discovered a molecular “switch” in a receptor that controls cell behavior.
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Peering into Cells One GPU at a Time
7 years ago

Peering into Cells One GPU at a Time

By  •  7 years ago  •  Science

A simulation of the internal workings of cells has reached a sustained performance of 20,000 trillion calculations per second, or 20 petaflops, on the Titan supercomputer at ORNL.
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Titan Shows Life Science Advancements at Bio-IT Conference

By  •  7 years ago  •  People

OLCF Director of Science Jack Wells spoke recently to the annual Bio-IT World Conference & Expo in Boston, sharing ORNL’s supercomputing experience.
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Big Computing Cures Big Pharma

By  •  8 years ago  •  Science

Researchers from ORNL and the University of Tennessee are using OLCF supercomputers to help cut time and risk in new drug development.
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ORNL Process Improves Catalytic Rate of Enzymes by 3,000 Percent

By  •  8 years ago  •  Science

In a paper published in The Journal of Physical Chemistry Letters, a team led by ORNL’s Pratul Agarwal described a process that aims to improve upon nature – and it happens in the blink of an eye.
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Researchers Show How Proteins Help DNA Replicate Past a Damaged Site

By  •  9 years ago  •  Science

Computation and experiment reveal how protein switching provides right tool for the job
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The Problem with Cellulosic Ethanol

By  •  9 years ago  •  Science

Simulation provides a close-up look at the molecule that complicates next-generation biofuels

Lignin is very handy in many ways. In your diet it provides much of the fiber that keeps …
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Researchers Pinpoint How Copper Folds Protein into Precursors of Parkinson’s Plaques

By  •  9 years ago  •  Science

Calculations on the Jaguar supercomputer reveal metal binding likely to misfold alpha-synuclein

Aided by the Jaguar supercomputer at Oak Ridge National Laboratory (ORNL), researchers at North Carolina State University have …
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Whole-Genome Sequencing Simulated on Supercomputers

By  •  9 years ago  •  Science

Using Jaguar, a research team led by Aleksei Aksimentiev, assistant professor in the physics department at the University of Illinois–Urbana-Champaign, began a project to create machines for personal genome sequencing that will be more accessible to hospitals.
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Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA

By  •  10 years ago  •  Science

Scientists use Jaguar to model replisome components to understand their role in health and disease.
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Potassium Channel Model Lights the Way for Simulations of Molecular Machines

By  •  12 years ago  •  Science

Supercomputers to reveal in atomistic detail all steps from open to closed ion channel
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Researchers Explore the Effectiveness of Alzheimer’s

By  •  13 years ago  •  Science

Scientists are exploring a new generation of drugs which have the potential to stop the growth of Alzheimer’s fibrils and disassemble them.
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