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Proteins

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Protein Design on Demand

Researchers used the world’s fastest supercomputer to train an artificial intelligence model to draw up blueprints for the building blocks of life. The study earned the multi-institutional team a finalist nomination for the Association for Computing Machinery’s Gordon Bell Prize, which honors innovation in applying high-performance computing to applications in science,…
Matt Lakin
November 14, 2024
TFIIH protein complexScience

New Insights Into a Shapeshifting Protein Complex

Transcription factor IIH, or TFIIH, pronounced “TF two H,” is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription — the highly regulated enzymatic synthesis of RNA from a DNA template — and in the repair of damaged DNA. But…
Coury Turczyn
July 7, 2023
ScienceTechnology

Solving the Protein Puzzle

A simple scoop of soil or water can hold an entire ecosystem–potentially millions or more microscopic organisms and the countless proteins they rely on to survive. Computations performed at the U.S. Department of Energy’s Oak Ridge National Laboratory could help count, sort and catalog each of those proteins in record…
Matt Lakin
October 28, 2022
Science

Shape-Based Model Sheds Light on Simplified Protein Binding

Can something as simple as shape fully determine whether or not proteins will bind together? Scientists are commissioning supercomputers to find out. A team led by Sharon Glotzer, distinguished professor and department chair of chemical engineering at the University of Michigan (UM), used the 200-petaflop Summit supercomputer at the US…
Rachel McDowell
August 9, 2021