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Biochemistry

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Protein Design on Demand

Researchers used the world’s fastest supercomputer to train an artificial intelligence model to draw up blueprints for the building blocks of life. The study earned the multi-institutional team a finalist nomination for the Association for Computing Machinery’s Gordon Bell Prize, which honors innovation in applying high-performance computing to applications in science,…
Matt Lakin
November 14, 2024
bradykinin ORNLScience

Lab Experiments Support the COVID-19 Bradykinin Storm Theory

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis—a theory that was posited 2 years ago by a team of researchers led by Systems Biologist Dan Jacobson at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL). At…
Coury Turczyn
September 14, 2022
Science

Summit Charts a Course to Uncover the Origins of Genetic Diseases

https://vimeo.com/336592112 A visualization of a new structure of the human PIC. The spheres correspond to the positions of patient-derived mutations color-coded by disease phenotype. Video credit: Ivaylo Ivanov, Georgia State University. Environmental conditions, lifestyle choices, chemical exposure, and foodborne and airborne pathogens are among the external factors that can cause…
Elizabeth Rosenthal
May 20, 2019
Science

Unraveling Enzymes

A team of researchers, led by Oak Ridge National Laboratory’s Pratul Agarwal, is seeking to obtain key insights into the fundamental underpinnings of how enzymes work and, in particular, what makes them such great catalysts.
Scott Jones
October 14, 2014