Protein Folding

Calculations on the Jaguar supercomputer reveal metal binding likely to misfold alpha-synuclein Alpha-synuclein, a protein that misfolds in Parkinson's disease, is shown in its free state (top) and bound to copper (bottom). Copper binding, detailed in the boxed area, accelerates the protein's misfolding. Image credit: Frisco Rose, Miroslav Hodak, and…