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DNA

TFIIH protein complex
Science
July 7, 2023

New Insights Into a Shapeshifting Protein Complex

Transcription factor IIH, or TFIIH, pronounced “TF two H,” is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription — the highly regulated enzymatic synthesis of RNA from a DNA template — and in the repair of damaged DNA. But…
Rad26-RNA polymerase II
Science
February 2, 2022

Decoding the Role of CSB Protein in DNA Repair

Using the Summit supercomputer at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL), a Georgia State University (GSU) research team has revealed the structural mechanism of the Cockayne Syndrome B (CSB) protein in transcription-coupled DNA repair. Led by GSU chemistry professor Ivaylo Ivanov, the team recently published…