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TFIIH protein complexScience

New Insights Into a Shapeshifting Protein Complex

Transcription factor IIH, or TFIIH, pronounced “TF two H,” is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription — the highly regulated enzymatic synthesis of RNA from a DNA template — and in the repair of damaged DNA. But…
Coury Turczyn
July 7, 2023
Rad26-RNA polymerase IIScience

Decoding the Role of CSB Protein in DNA Repair

Using the Summit supercomputer at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL), a Georgia State University (GSU) research team has revealed the structural mechanism of the Cockayne Syndrome B (CSB) protein in transcription-coupled DNA repair. Led by GSU chemistry professor Ivaylo Ivanov, the team recently published…
Coury Turczyn
February 2, 2022