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Summit Helps Veterans Affairs Connect Genetic Dots

To conduct a groundbreaking study of genetic data from more than half a million U.S. veterans, scientists needed tools of the kind found only at the Department of Energy’s Oak Ridge National Laboratory. "This particular study is probably the crown jewel of the field so far," said Ravi Madduri, a…
Matt Lakin
December 18, 2024
TFIIH protein complexScience

New Insights Into a Shapeshifting Protein Complex

Transcription factor IIH, or TFIIH, pronounced “TF two H,” is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription — the highly regulated enzymatic synthesis of RNA from a DNA template — and in the repair of damaged DNA. But…
Coury Turczyn
July 7, 2023
Science

Summit Charts a Course to Uncover the Origins of Genetic Diseases

https://vimeo.com/336592112 A visualization of a new structure of the human PIC. The spheres correspond to the positions of patient-derived mutations color-coded by disease phenotype. Video credit: Ivaylo Ivanov, Georgia State University. Environmental conditions, lifestyle choices, chemical exposure, and foodborne and airborne pathogens are among the external factors that can cause…
Elizabeth Rosenthal
May 20, 2019